Resources

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Lassa fever in post-conflict Sierra Leone

This resource presents observations of case fatality rates of Lassa fever in Sierra Leone after the civil war and compared to studies completed prior to the conflict. Peak presentation of Lassa fever cases occurs in the dry season, which is consistent with previous studies. This paper's studies also confirmed reports conducted prior to the civil war that indicate that infants, children, young adults, and pregnant women are disproportionately impacted by Lassa fever.

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WHO: Lassa fever research and development (R&D) roadmap

This resource provides a framework for identifying the vision, underpinning strategic goals, and prioritizing areas and activities for accelerating the collaborative development of medical countermeasures.

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Organizing the donation of convalescent plasma for a therapeutic clinical trial on Ebola Virus Disease: The experience in Guinea

This resource reports on the successful organization of donor mobilization and plasma collection as part of the Ebola-Tx clinical trial from November 2014 to July 2015 in Conakry, Guinea, the challenges they faced, and efforts made to address these.

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Power, fairness and trust : understanding and engaging with vaccine trial participants and communities in the setting up the EVOVAC-Salone vaccine trial in Sierra Leone

In this article the authors discuss the implementation of an Ebola vaccine trial in Kambia district in Sierra Leone during and after the epidemic. They analyze the role of social science research for the development of community engagement strategies. The authors give special attention to the analysis of rumours as source of information and explanation about resistance rooted in a much deeper sociopolitical context.

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Ebola: Limitations of correcting misinformation

In this resource, members of the Ebola Response Anthropology Platform call on all organisations involved in the response to the Ebola outbreak to question the assumption that biomedicine must correct local logics and concerns, and the effectiveness of using standardised advice for non-standardised situations.

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Lassa fever: The politics of an emerging disease and the scope for One Health

As a rodent borne virus, Lassa fever is of particular interest from a One Health perspective. The interplay between security, public health and One Health approaches are explored through ethnographic and interview based research in Kenema, Sierra Leone, a long-term treatment and research hub. ‘Biodefence dollars’ have provided the majority of recent funding in Sierra Leone and have created opportunities for both local and international actors to address a neglected disease.

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Rat-Atouille: A mixed method study to characterize rodent hunting and consumption in the context of Lassa fever

This paper investigated the consumption of rodents, including the reservoir species of Lassa fever, and found this is widespread and does not neatly tally against generational or gender lines. Further, it found that the reasons for rodent consumption are multifactorial, including taste preferences, food security, and opportunistic behaviour.

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On the origin of Ebola: Biomedical discourse versus popular interpretations in Macenta in Guinea

This resource describes the use of participative observation, informal conversations and in-depth interviews to identify rumours surrounding Ebola, their sources, and to understand the local population’s perception and knowledge about the history and origin of the Ebola outbreak in Guinea.

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Challenges in preparing and implementing a clinical trial at field level in an Ebola emergency: A case study in Guinea, West Africa

This resource describes the main challenges of the implementation of a trial in the Ebola treatment center of Guéckédou. Following the principles of the Good Clinical Research Practices, it reports the aspects of the community’s communication and engagement, ethical conduct, trial protocol compliance, informed consent of participants, ongoing benefit/risk assessment, record keeping, confidentiality of patients and study data, and roles and responsibilities of the actors involved.

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U.S. Centre for Disease Control (CDC): Lassa fever

Further information from the U.S. CDC in both English and French about the transmission, prevention, diagnosis and treatment of Lassa fever.

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