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Organizing the donation of convalescent plasma for a therapeutic clinical trial on Ebola Virus Disease: The experience in Guinea

This resource reports on the successful organization of donor mobilization and plasma collection as part of the Ebola-Tx clinical trial from November 2014 to July 2015 in Conakry, Guinea, the challenges they faced, and efforts made to address these.

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Healthcare providers on the frontlines: A qualitative investigation of the social and emotional impact of delivering health services during Sierra Leone’s Ebola epidemic

This paper describes the stigma experienced by health care workers during the Ebola epidemic in Sierra Leone, and recommends psychological support mechanisms for medical staff working in epidemic contexts.

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Hospital domestics: Care work in a Kenyan hospital

Though not about Lassa fever specifically, this paper explores the division of labour between medical staff and familial caregivers in Kenya.

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Perceptions of burden of caregiving by informal caregivers of cancer patients attending University of Calabar Teaching Hospital, Calabar, Nigeria

Though not about Lassa fever specifically, this study shows the burden experienced by informal caregivers of cancer patients in Nigeria. Most caregivers experienced this burden as moderate or severe.

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Participation of women and children in hunting activities in Sierra Leone and implications for control of zoonotic infections

This paper underscores the challenges of interventions, surveillance, research and sensitization campaigns. To address such complexity, intervention strategies should become more diversified and context-specific. In particular the role of children should be recognised; specific intervention strategies should be tailored to children's specific hunting practices.

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Rat-Atouille: A mixed method study to characterize rodent hunting and consumption in the context of Lassa fever

This paper investigated the consumption of rodents, including the reservoir species of Lassa fever, and found this is widespread and does not neatly tally against generational or gender lines. Further, it found that the reasons for rodent consumption are multifactorial, including taste preferences, food security, and opportunistic behaviour.

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Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea

This study comparing two regions in Guinea, Pita and Gueckedou, observed three major risks for Lassa virus transmission: rodent infestation, uncovered food and hunting of peridomestic rodents as protein source. Hunting and preparation of rodents was identify as a specific risk, however more research is needed to ascertain the age and sex-specific risk factors, sociocultural and economical leading to rodent consumption.

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Challenges in preparing and implementing a clinical trial at field level in an Ebola emergency: A case study in Guinea, West Africa

This resource describes the main challenges of the implementation of a trial in the Ebola treatment center of Guéckédou. Following the principles of the Good Clinical Research Practices, it reports the aspects of the community’s communication and engagement, ethical conduct, trial protocol compliance, informed consent of participants, ongoing benefit/risk assessment, record keeping, confidentiality of patients and study data, and roles and responsibilities of the actors involved.

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'He is now like a brother, I can even give him some blood': Relational ethics and material exchanges in a malaria vaccine 'trial community' in The Gambia

This paper explores social relations within the ‘trial community’ (staff and volunteers) of a Malaria Vaccine Trial (MVT), implemented by the Medical Research Council (MRC) in The Gambia between 2001 and 2004. It situates ethical concerns with medical research within the everyday life of scientific fieldwork. Based upon discussions with volunteers and staff, it looks at processes of mediation between scientific project and study population, between formal ethics, local ethical debates, and everyday practice.

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EBOVAC-Salone: Lessons learned from implementing an Ebola vaccine trial in an Ebola-affected country

This article describes the experiences of the EBOVAC-Salone research team in setting up and implementing the trial, and provides recommendations for research teams aiming to conduct clinical trials in future outbreak situations.

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