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New opportunities for field research on the pathogenesis and treatment of Lassa fever

This resource reviews the present literature on treatment and pathogenesis of Lassa fever and outlines priorities for future research in the field made possible by the improved research capacity of the Mano River Union countries of Sierra Leone, Liberia, and Guinea, Lassa fever network. 

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Engaging ‘communities’: Anthropological insights from the West African Ebola epidemic

This resource reflects on the nature of community engagement during the Ebola epidemic and demonstrates a disjuncture between local realities and what is being imagined in post-Ebola reports about the lessons that need to be learned for the future. It argues that to achieve stated aims of building trust and strengthening outbreak response and health systems, public health institutions need to reorientate their conceptualization of ‘the community’ and develop ways of working which take complex social and political relationships into account.

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Challenges in preparing and implementing a clinical trial at field level in an Ebola emergency: A case study in Guinea, West Africa

This resource describes the main challenges of the implementation of a trial in the Ebola treatment center of Guéckédou. Following the principles of the Good Clinical Research Practices, it reports the aspects of the community’s communication and engagement, ethical conduct, trial protocol compliance, informed consent of participants, ongoing benefit/risk assessment, record keeping, confidentiality of patients and study data, and roles and responsibilities of the actors involved.

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U.S. Centre for Disease Control (CDC): Lassa fever

Further information from the U.S. CDC in both English and French about the transmission, prevention, diagnosis and treatment of Lassa fever.

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U.S Centre for Disease Control (CDC): Ebola hemorrhagic fever information packet

This resource provides a fact sheet for Ebola as well as a case count and location list for April 9th, 2010.

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Safe intensive-care management of a severe case of Lassa fever with simple barrier nursing techniques

This resource describes the case-management of Lassa fever in a specific patient and the difficulties encountered in repatriating her for diagnosis and management, which is unavailable in Sierra Leone, are described.The experience with this case has implications for the medical care and safe handling of Lassa fever in both endemic and nonendemic areas.

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Lassa fever: Epidemiology, clinical features, and social consequences

This resource describes the epidemiology of Lassa fever and its vector, as well as the clinical course and management of the disease. It then reports on current treatment efforts, surveillance and disease control before presenting community perspectives through a knowledge, attitude and practice survey and a qualitative study.  

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WHO: Target product profile for Lassa virus vaccine

This resource is an outline of the WHO target product profile development  for Lassa, as well as a generic description of WHO's Vaccine Pre-qualification process.

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Lassa fever

In a study of Lassa fever in Sierra Leone, West Africa, this paper identifies two variables associated with a high risk of death, and evaluates the efficacy of ribavirin and Lassa virus–convalescent plasma for the treatment of Lassa fever.

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Risk maps of Lassa fever in West Africa

With the aim of gaining more information to control this disease, this paper carries out a spatial analysis of Lassa fever data from human cases and infected rodent hosts covering the period 1965–2007. 

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