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Evaluation of rodent control to fight Lassa fever based on field data and mathematical modelling

This resource aims to to assess the efficacy of rodent control by performing a 4-year field experiment in rural Upper Guinea, and developing a mathematical model to simulate different control strategies (annual density control, continuous density control, and rodent vaccination).

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Diversity and dynamics in a community of small mammals in coastal Guinea, West Africa

This resource investigated three villages in high endemic zones of Lassa fever in Guinea and presents the biodeiversity of the small mammal community identified through standardized trapping in houses, cultivations and forest.

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Organizing the donation of convalescent plasma for a therapeutic clinical trial on Ebola Virus Disease: The experience in Guinea

This resource reports on the successful organization of donor mobilization and plasma collection as part of the Ebola-Tx clinical trial from November 2014 to July 2015 in Conakry, Guinea, the challenges they faced, and efforts made to address these.

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Rodent control to fight Lassa fever: Evaluation and lessons learned from a 4-year study in Upper Guinea

This paper performed a 4 year intervention based on chemical rodent control, utilizing anticoagulant rodenticides in 3 villages and evaluating the rodent abundance before and after treatment. They found that chemical treatment provides an effective tool to control local rodent populations. Based on these findings and the acceptability of rodent control activities at community level, the authors aim to promote, in coordination with health and agricultural authorities, a more holistic approach, including rodent trapping and poisoning, environmental hygiene, personal hygiene, house repairs and rodent-proof storage.

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Treating corpses like bundles of firewood. On the social production of indifference in the time of Ebola (Guinea)

The authors reflect on the impacts of the declaration of global emergency on the way dead bodies were treated during the Ebola virus disease epidemic in Guinea: focusing on problems related to anonymous graves and the impossibility of organizing burial ceremonies.

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Fluctuation of abundance and Lassa virus prevalence in Mastomys Natalensis in Guinea, West Africa

This study investigates the link between the ecology of the M. Natalensis and the incidence of Lassa fever in human cases in Guinea. They found that the risk for Lassa virus transmission was present in both rainy and dry season; however the risk increased in the dry season because of the possibility of encountering rodent excreta in the houses.

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Movement patterns of small rodents in Lassa fever-endemic villages in Guinea

The authors investigate in this study the spatial behaviour of M. Natalensis in Upper Guinea. They use to experiments: capture-mark-recapture studies and Rhodamine B. Their findings showed that M.Natalensis moves between houses and proximate fields. This is an important information for rodent control activities that need to be extended from indoors to fields.

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Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea

This study comparing two regions in Guinea, Pita and Gueckedou, observed three major risks for Lassa virus transmission: rodent infestation, uncovered food and hunting of peridomestic rodents as protein source. Hunting and preparation of rodents was identify as a specific risk, however more research is needed to ascertain the age and sex-specific risk factors, sociocultural and economical leading to rodent consumption.

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On the origin of Ebola: Biomedical discourse versus popular interpretations in Macenta in Guinea

This resource describes the use of participative observation, informal conversations and in-depth interviews to identify rumours surrounding Ebola, their sources, and to understand the local population’s perception and knowledge about the history and origin of the Ebola outbreak in Guinea. 

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Challenges in preparing and implementing a clinical trial at field level in an Ebola emergency: A case study in Guinea, West Africa

This resource describes the main challenges of the implementation of a trial in the Ebola treatment center of Guéckédou. Following the principles of the Good Clinical Research Practices, it reports the aspects of the community’s communication and engagement, ethical conduct, trial protocol compliance, informed consent of participants, ongoing benefit/risk assessment, record keeping, confidentiality of patients and study data, and roles and responsibilities of the actors involved.

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