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Acute sensorineural deafness in Lassa fever

This resource describes a prospective audiometric evaluation of 69 hospitalized febrile patients in Sierra Leone, West Africa, that revealed a sensorineural hearing deficit (SNHD) in 14 (29%) of 49 confirmed cases of Lassa fever and in 0 of 20 febrile controls. This study found that lassa fever is associated with an incidence of SNHD, which considerably exceeds that previously reported with any other postnatally acquired infection.

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Lassa fever–induced sensorineural hearing loss: A neglected public health and social burden

This resource summarises clinical findings of hearing loss in Lassa fever (LF) patients highlighting the association between Lassa virus infection and sudden-onset sensorineural hearing loss (SNHL), as well as the potential mechanism(s) for LF-induced SNHL. The study highlights that further research is necessary to identify the mechanism and the epidemiology of LF-induced SNHL.

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World Health Organisation: Lassa fever in Sierra Leone

This is an update on Lassa fever in Sierra Leone from the 14th June 1996. 

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WHO: Lassa fever research and development (R&D) roadmap

This resource provides a framework for identifying the vision, underpinning strategic goals, and prioritizing areas and activities for accelerating the collaborative development of medical countermeasures.

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At home with Mastomys and Rattus: Human-rodent interactions and potential for primary transmission of Lassa virus in domestic spaces

In this study housing characteristics and domestic organization were fund to have an impact on the direct and indirect, intentional and unintentional contact with rodents indoors. More research on housing and environmental modification, as well as food storage are important for prevention against LASV transmission.

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The process and practice of diagnosis: Innovations in diagnostics for Lassa fever in Sierra Leone

Chapter 5 of Annie Wilkinson’s PhD thesis, provides a detailed description of health seeking behaviours for Lassa Fever in rural Sierra Leone. In this context, people interpreted and managed Lassa Fever in light of their familiarity with a wide range of other diseases, some of which were viewed as dangerous and others less so; in contexts where sickness, health and treatment were marked by uncertainty; and where hospitals were not necessarily perceived to be sites of good care.  An important insight is that people differentiated ‘big sick’ or ‘hospital sick’ from an ordinary or ‘small’ sick and it was partly on the basis of this distinction that people would choose to access care.

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Healthcare providers on the frontlines: A qualitative investigation of the social and emotional impact of delivering health services during Sierra Leone’s Ebola epidemic

This paper describes the stigma experienced by health care workers during the Ebola epidemic in Sierra Leone, and recommends psychological support mechanisms for medical staff working in epidemic contexts.

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Burials in times of Ebola: Do's and don'ts - issues of acceptability

This short guide was elaborated by the authors at the beginning of the Ebola Virus disease outbreak in May 2014 in Gueckedou base on a fieldwork in the area. It compiles the wishes collected from villages where people died from Ebola virus diseases.

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Lessons from the West Africa Ebola epidemic: A systematic review of epidemiological and social and behavioral science research priorities

This systematic literature review compared the epidemiological (EPI) research and the qualitative social and behavioral science (SBS) research published during the West Africa Ebola virus disease (EVD) epidemic. The findings support a program of action that situates data collection and analysis in real-time, recursive, integrated efforts to move community attitudes, behaviors, and responses into epidemiological research, and the paper offers recommendations to improve coordinated, multidisciplinary approaches to health emergencies.

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Power, fairness and trust : understanding and engaging with vaccine trial participants and communities in the setting up the EVOVAC-Salone vaccine trial in Sierra Leone

In this article the authors discuss the implementation of an Ebola vaccine trial in Kambia district in Sierra Leone during and after the epidemic. They analyze the role of social science research for the development of community engagement strategies. The authors give special attention to the analysis of rumours as source of information and explanation about resistance rooted in a much deeper sociopolitical context.

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